Resident Population in Cherokee County, SC was 56.71400 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in Cherokee County, SC reached a record high of 57.33100 in January of 2019 and a record low of 36.66900 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Cherokee County, SC - last updated from the United States Federal Reserve on May of 2024.